KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism

The histone lysine demethylase KDM4C is often overexpressed in cancers primarily through gene amplification. The molecular mechanisms of KDM4C action in tumorigenesis are not well defined. Here we report that KDM4C transcriptionally activates amino acid biosynthesis and transport, leading to a signi...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Zhao, Erhu, Ding, Jane, Xia, Yingfeng, Liu, Mengling, Ye, Bingwei, Choi, Jeong-Hyeon, Yan, Chunhong, Dong, Zheng, Huang, Shuang, Zha, Yunhong, Yang, Liqun, Cui, Hongjuan, Ding, Han-Fei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731315/
https://ncbi.nlm.nih.gov/pubmed/26774480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.053
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