The Histone H3 Methyltransferase G9A Epigenetically Activates the Serine-Glycine Synthesis Pathway to Sustain Cancer Cell Survival and Proliferation

Increased activation of the serine-glycine biosynthetic pathway is an integral part of cancer metabolism that drives macromolecule synthesis needed for cell proliferation. Whether this pathway is under epigenetic control is unknown. Here we show that the histone H3 lysine 9 (H3K9) methyltransferase...

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Detalhes bibliográficos
Main Authors: Ding, Jane, Li, Tai, Wang, Xiangwei, Zhao, Erhu, Choi, Jeong-Hyeon, Yang, Liqun, Zha, Yunhong, Dong, Zheng, Huang, Shuang, Asara, John M., Cui, Hongjuan, Ding, Han-Fei
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3878056/
https://ncbi.nlm.nih.gov/pubmed/24315373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.11.004
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