Metabolic reprogramming by MYCN confers dependence on the serine-glycine-one-carbon biosynthetic pathway

MYCN amplification drives the development of neuronal cancers in children and adults. Given the challenge in therapeutically targeting MYCN directly, we searched for MYCN-activated metabolic pathways as potential drug targets. Here we report that neuroblastoma cells with MYCN amplification show incr...

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Publicado en:Cancer Res
Autores principales: Xia, Yingfeng, Ye, Bingwei, Ding, Jane, Yu, Yajie, Alptekin, Ahmet, Thangaraju, Muthusamy, Prasad, Puttur D., Ding, Zhi-Chun, Park, Eun Jeong, Choi, Jeong-Hyeon, Gao, Bei, Fiehn, Oliver, Yan, Chunhong, Dong, Zheng, Zha, Yunhong, Ding, Han-Fei
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679782/
https://ncbi.nlm.nih.gov/pubmed/31088832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-3541
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