Metabolic reprogramming by MYCN confers dependence on the serine-glycine-one-carbon biosynthetic pathway

MYCN amplification drives the development of neuronal cancers in children and adults. Given the challenge in therapeutically targeting MYCN directly, we searched for MYCN-activated metabolic pathways as potential drug targets. Here we report that neuroblastoma cells with MYCN amplification show incr...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Xia, Yingfeng, Ye, Bingwei, Ding, Jane, Yu, Yajie, Alptekin, Ahmet, Thangaraju, Muthusamy, Prasad, Puttur D., Ding, Zhi-Chun, Park, Eun Jeong, Choi, Jeong-Hyeon, Gao, Bei, Fiehn, Oliver, Yan, Chunhong, Dong, Zheng, Zha, Yunhong, Ding, Han-Fei
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679782/
https://ncbi.nlm.nih.gov/pubmed/31088832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-3541
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados