Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7–dependent lupus

The peptidylarginine deiminases PAD2 and PAD4 are implicated in the pathogenesis of several autoimmune diseases. PAD4 may be pathogenic in systemic lupus erythematosus (SLE) through its role in neutrophil extracellular trap (NET) formation that promotes autoantigen externalization, immune dysregulat...

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Udgivet i:JCI Insight
Main Authors: Liu, Yudong, Lightfoot, Yaíma L., Seto, Nickie, Carmona-Rivera, Carmelo, Moore, Erica, Goel, Rishi, O’Neil, Liam, Mistry, Pragnesh, Hoffmann, Victoria, Mondal, Santanu, Premnath, Padmavathy Nandha, Gribbons, Katherine, Dell’Orso, Stefania, Jiang, Kan, Thompson, Paul R., Sun, Hong-Wei, Coonrod, Scott A., Kaplan, Mariana J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328098/
https://ncbi.nlm.nih.gov/pubmed/30518690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124729
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