Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7–dependent lupus

The peptidylarginine deiminases PAD2 and PAD4 are implicated in the pathogenesis of several autoimmune diseases. PAD4 may be pathogenic in systemic lupus erythematosus (SLE) through its role in neutrophil extracellular trap (NET) formation that promotes autoantigen externalization, immune dysregulat...

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Опубликовано в: :JCI Insight
Главные авторы: Liu, Yudong, Lightfoot, Yaíma L., Seto, Nickie, Carmona-Rivera, Carmelo, Moore, Erica, Goel, Rishi, O’Neil, Liam, Mistry, Pragnesh, Hoffmann, Victoria, Mondal, Santanu, Premnath, Padmavathy Nandha, Gribbons, Katherine, Dell’Orso, Stefania, Jiang, Kan, Thompson, Paul R., Sun, Hong-Wei, Coonrod, Scott A., Kaplan, Mariana J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2018
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328098/
https://ncbi.nlm.nih.gov/pubmed/30518690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124729
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