Defining the human C2H2 zinc-finger degrome targeted by thalidomide analogs through CRBN

The small molecules thalidomide, lenalidomide, and pomalidomide induce the ubiquitination and proteasomal degradation of the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) by recruiting a Cys2-His2 (C2H2) zinc finger domain to Cereblon (CRBN), the substrate receptor of the CRL4(CRBN) E3 ubi...

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Publicat a:Science
Autors principals: Sievers, Quinlan L., Petzold, Georg, Bunker, Richard D., Renneville, Aline, Słabicki, Mikołaj, Liddicoat, Brian J., Abdulrahman, Wassim, Mikkelsen, Tarjei, Ebert, Benjamin L., Thomä, Nicolas H.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326779/
https://ncbi.nlm.nih.gov/pubmed/30385546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aat0572
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