Defining the human C2H2 zinc-finger degrome targeted by thalidomide analogs through CRBN

The small molecules thalidomide, lenalidomide, and pomalidomide induce the ubiquitination and proteasomal degradation of the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) by recruiting a Cys2-His2 (C2H2) zinc finger domain to Cereblon (CRBN), the substrate receptor of the CRL4(CRBN) E3 ubi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Science
Prif Awduron: Sievers, Quinlan L., Petzold, Georg, Bunker, Richard D., Renneville, Aline, Słabicki, Mikołaj, Liddicoat, Brian J., Abdulrahman, Wassim, Mikkelsen, Tarjei, Ebert, Benjamin L., Thomä, Nicolas H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326779/
https://ncbi.nlm.nih.gov/pubmed/30385546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aat0572
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg