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Regulation of AMPK Activity by CRBN Is Independent of the Thalidomide-CRL4(CRBN) Protein Degradation Axis
Cereblon (CRBN), a primary target of immune-modulatory imide drugs (IMiDs), functions as a substrate receptor in the CUL4-RBX1-DDB1-CRBN (known as CRL4(CRBN)) E3 ubiquitin ligase complex. Binding of IMiDs to CRBN redirects the CRL4(CRBN) E3 ubiquitin ligase to recruit or displace its substrates. Int...
Gardado en:
| Publicado en: | Pharmaceuticals (Basel) |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
MDPI
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8228114/ https://ncbi.nlm.nih.gov/pubmed/34073624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14060512 |
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