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Regulation of AMPK Activity by CRBN Is Independent of the Thalidomide-CRL4(CRBN) Protein Degradation Axis

Cereblon (CRBN), a primary target of immune-modulatory imide drugs (IMiDs), functions as a substrate receptor in the CUL4-RBX1-DDB1-CRBN (known as CRL4(CRBN)) E3 ubiquitin ligase complex. Binding of IMiDs to CRBN redirects the CRL4(CRBN) E3 ubiquitin ligase to recruit or displace its substrates. Int...

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Bibliografische gegevens
Gepubliceerd in:Pharmaceuticals (Basel)
Hoofdauteurs: Yang, Seung-Joo, Jeon, Seungje, Baek, Jeong Won, Lee, Kwang Min, Park, Chul-Seung
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8228114/
https://ncbi.nlm.nih.gov/pubmed/34073624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14060512
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