Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide

In the 1950s the drug thalidomide administered as a sedative to pregnant women led to the birth of thousands of children with multiple defects. Despite its teratogenicity, thalidomide and its derivatives lenalidomide and pomalidomide (together known as Immunomodulatory Drugs: IMiDs) recently emerged...

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Gepubliceerd in:Nature
Hoofdauteurs: Fischer, Eric S., Böhm, Kerstin, Lydeard, John R., Yang, Haidi, Stadler, Michael B., Cavadini, Simone, Nagel, Jane, Serluca, Fabrizio, Acker, Vincent, Lingaraju, Gondichatnahalli M., Tichkule, Ritesh B., Schebesta, Michael, Forrester, William C., Schirle, Markus, Hassiepen, Ulrich, Ottl, Johannes, Hild, Marc, Beckwith, Rohan E. J., Harper, J. Wade, Jenkins, Jeremy L., Thomä, Nicolas H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423819/
https://ncbi.nlm.nih.gov/pubmed/25043012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13527
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