Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide

In the 1950s the drug thalidomide administered as a sedative to pregnant women led to the birth of thousands of children with multiple defects. Despite its teratogenicity, thalidomide and its derivatives lenalidomide and pomalidomide (together known as Immunomodulatory Drugs: IMiDs) recently emerged...

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書誌詳細
出版年:Nature
主要な著者: Fischer, Eric S., Böhm, Kerstin, Lydeard, John R., Yang, Haidi, Stadler, Michael B., Cavadini, Simone, Nagel, Jane, Serluca, Fabrizio, Acker, Vincent, Lingaraju, Gondichatnahalli M., Tichkule, Ritesh B., Schebesta, Michael, Forrester, William C., Schirle, Markus, Hassiepen, Ulrich, Ottl, Johannes, Hild, Marc, Beckwith, Rohan E. J., Harper, J. Wade, Jenkins, Jeremy L., Thomä, Nicolas H.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423819/
https://ncbi.nlm.nih.gov/pubmed/25043012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13527
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