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Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation

[Image: see text] We have recently shown that 2-aminoimidazole is a superior nucleotide activating group for nonenzymatic RNA copying. Here we describe a prebiotic synthesis of 2-aminoimidazole that shares a common mechanistic pathway with that of 2-aminooxazole, a previously described key intermedi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Chem Soc
Prif Awduron: Fahrenbach, Albert C., Giurgiu, Constantin, Tam, Chun Pong, Li, Li, Hongo, Yayoi, Aono, Masashi, Szostak, Jack W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2017
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326526/
https://ncbi.nlm.nih.gov/pubmed/28640999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b01562
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