Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer–Template Complexes

[Image: see text] Origins of life hypotheses often invoke a transitional phase of nonenzymatic template-directed RNA replication prior to the emergence of ribozyme-catalyzed copying of genetic information. Here, using NMR and ITC, we interrogate the binding affinity of guanosine 5′-monophosphate (GM...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Tam, Chun Pong, Fahrenbach, Albert C., Björkbom, Anders, Prywes, Noam, Izgu, Enver Cagri, Szostak, Jack W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7547879/
https://ncbi.nlm.nih.gov/pubmed/28055190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b09760
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