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Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer–Template Complexes
[Image: see text] Origins of life hypotheses often invoke a transitional phase of nonenzymatic template-directed RNA replication prior to the emergence of ribozyme-catalyzed copying of genetic information. Here, using NMR and ITC, we interrogate the binding affinity of guanosine 5′-monophosphate (GM...
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| Опубликовано в: : | J Am Chem Soc |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Chemical
Society
2017
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| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7547879/ https://ncbi.nlm.nih.gov/pubmed/28055190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b09760 |
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