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Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex
The nonenzymatic copying of RNA templates with imidazole-activated nucleotides is a well-studied model for the emergence of RNA self-replication during the origin of life. We have recently discovered that this reaction can proceed through the formation of an imidazolium-bridged dinucleotide intermed...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5530681/ https://ncbi.nlm.nih.gov/pubmed/28673998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704006114 |
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