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Template-Directed Catalysis of a Multistep Reaction Pathway for Nonenzymatic RNA Primer Extension

[Image: see text] Before the advent of polymerase enzymes, the copying of genetic material during the origin of life may have involved the nonenzymatic polymerization of RNA monomers that are more reactive than the biological nucleoside triphosphates. Activated RNA monomers such as nucleotide 5′-pho...

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Bibliografske podrobnosti
izdano v:Biochemistry
Main Authors: Walton, Travis, Pazienza, Lydia, Szostak, Jack W.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2018
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7547881/
https://ncbi.nlm.nih.gov/pubmed/30566332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01156
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