Synthesis of N3′-P5′-linked Phosphoramidate DNA by Nonenzymatic Template-Directed Primer Extension

[Image: see text] A fast and accurate pathway for nonenzymatic RNA replication would simplify models for the emergence of the RNA world from the prebiotic chemistry of the early earth. However, numerous difficulties stand in the way of an experimental demonstration of effective nonenzymatic RNA repl...

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Bibliografiske detaljer
Main Authors: Zhang, Shenglong, Zhang, Na, Blain, J. Craig, Szostak, Jack W.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2012
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548433/
https://ncbi.nlm.nih.gov/pubmed/23252395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja311164j
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