A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension

[Image: see text] A working model of nonenzymatic RNA primer extension could illuminate how prebiotic chemistry transitioned to biology. All currently known experimental reconstructions of nonenzymatic RNA primer extension yield a mixture of 2′-5′ and 3′-5′ internucleotide linkages. Although long se...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Chem Soc
Prif Awduron: Giurgiu, Constantin, Li, Li, O’Flaherty, Derek K., Tam, Chun Pong, Szostak, Jack W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2017
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326530/
https://ncbi.nlm.nih.gov/pubmed/29112424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b08784
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