Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly

The transition of the Munc18-1/syntaxin-1 complex to the SNARE complex, a key step involved in exocytosis, is regulated by Munc13-1, SNAP-25 and synaptobrevin-2, but the underlying mechanism remains elusive. Here, we identify an interaction between Munc13-1 and the membrane-proximal linker region of...

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Published in:Nat Commun
Main Authors: Wang, Shen, Li, Yun, Gong, Jihong, Ye, Sheng, Yang, Xiaofei, Zhang, Rongguang, Ma, Cong
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325239/
https://ncbi.nlm.nih.gov/pubmed/30622273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08028-6
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