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Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly
The transition of the Munc18-1/syntaxin-1 complex to the SNARE complex, a key step involved in exocytosis, is regulated by Munc13-1, SNAP-25 and synaptobrevin-2, but the underlying mechanism remains elusive. Here, we identify an interaction between Munc13-1 and the membrane-proximal linker region of...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6325239/ https://ncbi.nlm.nih.gov/pubmed/30622273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08028-6 |
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