Use of Translational Pharmacokinetic/Pharmacodynamic Infection Models To Understand the Impact of Neutropenia on the Efficacy of Tedizolid Phosphate

Tedizolid phosphate, the prodrug of the active antibiotic tedizolid, is an oxazolidinone for the treatment of acute bacterial skin and skin structure infections. Studies in a mouse thigh infection model demonstrated that tedizolid has improved potency and pharmacokinetics/pharmacodynamics (PK/PD) co...

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Bibliografische gegevens
Gepubliceerd in:Antimicrob Agents Chemother
Hoofdauteurs: Xiao, Jianying, Gill, Charles, Liang, Lianzhu, Liu, Jenny, Wu, Jin, Feng, Hwa-Ping, Flanagan, Shawn, Tan, Christopher, Flattery, Amy
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2018
Onderwerpen:
Pharmacology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325206/
https://ncbi.nlm.nih.gov/pubmed/30373794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00822-18
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