Use of Translational Pharmacokinetic/Pharmacodynamic Infection Models To Understand the Impact of Neutropenia on the Efficacy of Tedizolid Phosphate

Tedizolid phosphate, the prodrug of the active antibiotic tedizolid, is an oxazolidinone for the treatment of acute bacterial skin and skin structure infections. Studies in a mouse thigh infection model demonstrated that tedizolid has improved potency and pharmacokinetics/pharmacodynamics (PK/PD) co...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Antimicrob Agents Chemother
Κύριοι συγγραφείς: Xiao, Jianying, Gill, Charles, Liang, Lianzhu, Liu, Jenny, Wu, Jin, Feng, Hwa-Ping, Flanagan, Shawn, Tan, Christopher, Flattery, Amy
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2018
Θέματα:
Pharmacology
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325206/
https://ncbi.nlm.nih.gov/pubmed/30373794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00822-18
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