Use of Translational Pharmacokinetic/Pharmacodynamic Infection Models To Understand the Impact of Neutropenia on the Efficacy of Tedizolid Phosphate

Tedizolid phosphate, the prodrug of the active antibiotic tedizolid, is an oxazolidinone for the treatment of acute bacterial skin and skin structure infections. Studies in a mouse thigh infection model demonstrated that tedizolid has improved potency and pharmacokinetics/pharmacodynamics (PK/PD) co...

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Bibliografiset tiedot
Julkaisussa:Antimicrob Agents Chemother
Päätekijät: Xiao, Jianying, Gill, Charles, Liang, Lianzhu, Liu, Jenny, Wu, Jin, Feng, Hwa-Ping, Flanagan, Shawn, Tan, Christopher, Flattery, Amy
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2018
Aiheet:
Pharmacology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325206/
https://ncbi.nlm.nih.gov/pubmed/30373794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00822-18
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