Use of Translational Pharmacokinetic/Pharmacodynamic Infection Models To Understand the Impact of Neutropenia on the Efficacy of Tedizolid Phosphate

Tedizolid phosphate, the prodrug of the active antibiotic tedizolid, is an oxazolidinone for the treatment of acute bacterial skin and skin structure infections. Studies in a mouse thigh infection model demonstrated that tedizolid has improved potency and pharmacokinetics/pharmacodynamics (PK/PD) co...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Antimicrob Agents Chemother
Main Authors: Xiao, Jianying, Gill, Charles, Liang, Lianzhu, Liu, Jenny, Wu, Jin, Feng, Hwa-Ping, Flanagan, Shawn, Tan, Christopher, Flattery, Amy
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2018
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325206/
https://ncbi.nlm.nih.gov/pubmed/30373794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00822-18
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