Zidovudine-Mediated Autophagy Inhibition Enhances Mitochondrial Toxicity in Muscle Cells

Nucleoside reverse transcriptase inhibitors (NRTI), such as zidovudine (AZT), are constituents of HIV-1 therapy and are used for the prevention of mother-to-child transmission. Prolonged thymidine analogue exposure has been associated with mitochondrial toxicities to heart, liver, and skeletal muscl...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Lin, H., Stankov, M. V., Hegermann, J., Budida, R., Panayotova-Dimitrova, D., Schmidt, R. E., Behrens, G. M. N.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325205/
https://ncbi.nlm.nih.gov/pubmed/30373793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01443-18
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