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Zidovudine Inhibits Thymidine Phosphorylation in the Isolated Perfused Rat Heart
Zidovudine (AZT; 3′-azido-3′-deoxythymidine), a thymidine analog, has been a staple of highly active antiretroviral therapy. It is phosphorylated in the host to the triphosphate and functions by inhibiting the viral reverse transcriptase. However, long-term use of AZT is linked to various tissue tox...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1855461/ https://ncbi.nlm.nih.gov/pubmed/17220403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01227-06 |
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