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Effect of AZT on thymidine phosphorylation in cultured H9c2, U-937, and Raji cell lines
3′-azido-3′-deoxythymidine (AZT) has been shown to be a potent inhibitor of thymidine kinase 2 in work from this laboratory. Inhibition results in decreased salvage of thymidine to TTP, which may lead to depletion of the TTP pool and result in the mitochondrial dysfunction and mt-DNA depletion obser...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2364649/ https://ncbi.nlm.nih.gov/pubmed/18295188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.01.006 |
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