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3′-Azido-3′-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: A possible mechanism of AZT hepatotoxicity

3′-Azido-3′-deoxythymidine (AZT) is a staple of highly active antiretroviral therapy (HAART). Prior to HAART, long-term use of high-dosage AZT caused myopathy, cardiomyopathy, and hepatotoxicity, associated with mitochondrial DNA depletion. As a component of HARRT, AZT causes cytopenias and lipodyst...

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Autores principales: Lynx, Matthew D., Bentley, Alice T., McKee, Edward E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2006
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472706/
https://ncbi.nlm.nih.gov/pubmed/16472780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2006.01.003
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