3'-azido-3'-deoxythymidine (AZT) monophosphate: an inhibitor of exonucleolytic repair of AZT-terminated DNA.

A 3'-exonuclease(s) that excised 3'-azido-3'-deoxythymidine (AZT) monophosphate (AZTMP) from the 3' terminus of DNA was partially purified from two human cell lines. AZTMP inhibited the hydrolysis of AZTMP-terminated single-stranded and double-stranded DNA substrates. Thus, high levels of AZTMP migh...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Harrington, J A, Reardon, J E, Spector, T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187815/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8388206/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.4.918
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