3′-Azido-3′-Deoxythymidine (AZT) and AZT-Resistant Reverse Transcriptase Can Increase the In Vivo Mutation Rate of Human Immunodeficiency Virus Type 1

How antiretroviral drug resistance influences human immunodeficiency virus type 1 (HIV-1) evolution is not clear. This study tested the hypothesis that antiretroviral drugs such as 3′-azido-3′-deoxythymidine (AZT) can influence the in vivo mutation rate of HIV-1. It was observed that AZT can increas...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Mansky, Louis M., Bernard, Lisa C.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Vaccines and Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112383/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11000223/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.20.9532-9539.2000
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