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3'-azido-3'-deoxythymidine (AZT) monophosphate: an inhibitor of exonucleolytic repair of AZT-terminated DNA.

A 3'-exonuclease(s) that excised 3'-azido-3'-deoxythymidine (AZT) monophosphate (AZTMP) from the 3' terminus of DNA was partially purified from two human cell lines. AZTMP inhibited the hydrolysis of AZTMP-terminated single-stranded and double-stranded DNA substrates. Thus, high levels of AZTMP migh...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Harrington, J A, Reardon, J E, Spector, T
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187815/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8388206/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.4.918
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