載入...

3′-Azido-3′-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: A possible mechanism of AZT hepatotoxicity

3′-Azido-3′-deoxythymidine (AZT) is a staple of highly active antiretroviral therapy (HAART). Prior to HAART, long-term use of high-dosage AZT caused myopathy, cardiomyopathy, and hepatotoxicity, associated with mitochondrial DNA depletion. As a component of HARRT, AZT causes cytopenias and lipodyst...

全面介紹

Na minha lista:
書目詳細資料
Main Authors: Lynx, Matthew D., Bentley, Alice T., McKee, Edward E.
格式: Artigo
語言:Inglês
出版: 2006
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472706/
https://ncbi.nlm.nih.gov/pubmed/16472780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2006.01.003
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!