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Effects of Zidovudine and Stavudine on Mitochondrial DNA of Differentiating 3T3-F442a Cells Are Not Associated with Imbalanced Deoxynucleotide Pools

To test whether zidovudine (3′-azido-3′-deoxythymidine) (AZT) inhibition of thymidine phosphorylation causes depletion of the TTP pool resulting in mitochondrial DNA depletion, 3T3-F442a cells were differentiated in the presence of AZT and analyzed to determine mitochondrial DNA content and deoxynuc...

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Bibliografske podrobnosti
Main Authors: Lynx, Matthew D., LaClair, Darcy D., McKee, Edward E.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650558/
https://ncbi.nlm.nih.gov/pubmed/19104011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01115-08
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