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Zidovudine Induces Downregulation of Mitochondrial Deoxynucleoside Kinases: Implications for Mitochondrial Toxicity of Antiviral Nucleoside Analogs

Mitochondrial thymidine kinase 2 (TK2) and deoxyguanosine kinase (dGK) catalyze the initial phosphorylation of deoxynucleosides in the synthesis of the DNA precursors required for mitochondrial DNA (mtDNA) replication and are essential for mitochondrial function. Antiviral nucleosides are known to c...

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Bibliografische gegevens
Gepubliceerd in:Antimicrob Agents Chemother
Hoofdauteurs: Sun, Ren, Eriksson, Staffan, Wang, Liya
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249380/
https://ncbi.nlm.nih.gov/pubmed/25182642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03613-14
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