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Basic biochemical characterization of cytosolic enzymes in thymidine nucleotide synthesis in adult rat tissues: implications for tissue specific mitochondrial DNA depletion and deoxynucleoside-based therapy for TK2-deficiency

BACKGROUND: Deficiency in thymidine kinase 2 (TK2) or p53 inducible ribonucleotide reductase small subunit (p53R2) is associated with tissue specific mitochondrial DNA (mtDNA) depletion. To understand the mechanisms of the tissue specific mtDNA depletion we systematically studied key enzymes in dTMP...

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Bibliografiske detaljer
Udgivet i:BMC Mol Cell Biol
Main Authors: Wang, Liya, Sun, Ren, Eriksson, Staffan
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7189545/
https://ncbi.nlm.nih.gov/pubmed/32345222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-020-00272-3
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