Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161

Tetrazole antifungals designed to target fungal lanosterol 14α-demethylase (LDM) appear to be effective against a range of fungal pathogens. In addition, a crystal structure of the catalytic domain of Candida albicans LDM in complex with the tetrazole VT-1161 has been obtained. We have addressed con...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Monk, Brian C., Keniya, Mikhail V., Sabherwal, Manya, Wilson, Rajni K., Graham, Danyon O., Hassan, Harith F., Chen, Danni, Tyndall, Joel D. A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325177/
https://ncbi.nlm.nih.gov/pubmed/30397057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02114-18
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