Mutations in the MAB_2299c TetR Regulator Confer Cross-Resistance to Clofazimine and Bedaquiline in Mycobacterium abscessus

New therapeutic approaches are needed against Mycobacterium abscessus, a respiratory mycobacterial pathogen that evades efforts to successfully treat infected patients. Clofazimine and bedaquiline, two drugs used for the treatment of multidrug-resistant tuberculosis, are being considered as alternat...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Richard, Matthias, Gutiérrez, Ana Victoria, Viljoen, Albertus, Rodriguez-Rincon, Daniela, Roquet-Baneres, Françoise, Blaise, Mickael, Everall, Isobel, Parkhill, Julian, Floto, R. Andres, Kremer, Laurent
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325171/
https://ncbi.nlm.nih.gov/pubmed/30323043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01316-18
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