Verapamil Improves the Activity of Bedaquiline against Mycobacterium abscessus In Vitro and in Macrophages

Due to intrinsic multidrug resistance, pulmonary infections with Mycobacterium abscessus are extremely difficult to treat. Previously, we demonstrated that bedaquiline is highly effective against Mycobacterium abscessus both in vitro and in vivo. Here, we report that verapamil improves the efficacy...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Viljoen, Albertus, Raynaud, Clément, Johansen, Matt D., Roquet-Banères, Françoise, Herrmann, Jean-Louis, Daher, Wassim, Kremer, Laurent
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2019
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Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709475/
https://ncbi.nlm.nih.gov/pubmed/31209005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00705-19
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