Verapamil Improves the Activity of Bedaquiline against Mycobacterium abscessus In Vitro and in Macrophages

Due to intrinsic multidrug resistance, pulmonary infections with Mycobacterium abscessus are extremely difficult to treat. Previously, we demonstrated that bedaquiline is highly effective against Mycobacterium abscessus both in vitro and in vivo. Here, we report that verapamil improves the efficacy...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Viljoen, Albertus, Raynaud, Clément, Johansen, Matt D., Roquet-Banères, Françoise, Herrmann, Jean-Louis, Daher, Wassim, Kremer, Laurent
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709475/
https://ncbi.nlm.nih.gov/pubmed/31209005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00705-19
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