Mechanistic and Structural Insights Into the Unique TetR-Dependent Regulation of a Drug Efflux Pump in Mycobacterium abscessus

Mycobacterium abscessus is an emerging human pathogen causing severe pulmonary infections and is refractory to standard antibiotherapy, yet few drug resistance mechanisms have been reported in this organism. Recently, mutations in MAB_4384 leading to up-regulation of the MmpS5/MmpL5 efflux pump were...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Richard, Matthias, Gutiérrez, Ana Victoria, Viljoen, Albertus J., Ghigo, Eric, Blaise, Mickael, Kremer, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5895659/
https://ncbi.nlm.nih.gov/pubmed/29675007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.00649
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