Mechanistic and Structural Insights Into the Unique TetR-Dependent Regulation of a Drug Efflux Pump in Mycobacterium abscessus

Mycobacterium abscessus is an emerging human pathogen causing severe pulmonary infections and is refractory to standard antibiotherapy, yet few drug resistance mechanisms have been reported in this organism. Recently, mutations in MAB_4384 leading to up-regulation of the MmpS5/MmpL5 efflux pump were...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Front Microbiol
Päätekijät: Richard, Matthias, Gutiérrez, Ana Victoria, Viljoen, Albertus J., Ghigo, Eric, Blaise, Mickael, Kremer, Laurent
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2018
Aiheet:
Microbiology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5895659/
https://ncbi.nlm.nih.gov/pubmed/29675007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.00649
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