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Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1
P-glycoprotein extrudes a large variety of xenobiotics from the cell, thereby protecting tissues from their toxic effects. The machinery underlying unidirectional multidrug pumping remains unknown, largely due to the lack of high-resolution structural information regarding the alternate conformation...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6325147/ https://ncbi.nlm.nih.gov/pubmed/30622258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08007-x |
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