Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog

P-glycoprotein is an ATP-binding cassette multidrug transporter that actively transports chemically diverse substrates across the lipid bilayer. The precise molecular mechanism underlying transport is not fully understood. Here, we present crystal structures of a eukaryotic P-glycoprotein homolog, C...

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Bibliografiske detaljer
Main Authors: Kodan, Atsushi, Yamaguchi, Tomohiro, Nakatsu, Toru, Sakiyama, Keita, Hipolito, Christopher J., Fujioka, Akane, Hirokane, Ryo, Ikeguchi, Keiji, Watanabe, Bunta, Hiratake, Jun, Kimura, Yasuhisa, Suga, Hiroaki, Ueda, Kazumitsu, Kato, Hiroaki
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964115/
https://ncbi.nlm.nih.gov/pubmed/24591620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321562111
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