Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol

MDR1 (multidrug resistance 1)/P-glycoprotein is an ATP-driven transporter which excretes a wide variety of structurally unrelated hydrophobic compounds from cells. It is suggested that drugs bind to MDR1 directly from the lipid bilayer and that cholesterol in the bilayer also interacts with MDR1. Ho...

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Detalhes bibliográficos
Main Authors: Kimura, Yasuhisa, Kioka, Noriyuki, Kato, Hiroaki, Matsuo, Michinori, Ueda, Kazumitsu
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820799/
https://ncbi.nlm.nih.gov/pubmed/17029589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060632
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