Fomiroid A, a Novel Compound from the Mushroom Fomitopsis nigra, Inhibits NPC1L1-Mediated Cholesterol Uptake via a Mode of Action Distinct from That of Ezetimibe

Hypercholesterolemia is one of the key risk factors for coronary heart disease, a major cause of death in developed countries. Suppression of NPC1L1-mediated dietary and biliary cholesterol absorption is predicted to be one of the most effective ways to reduce the risk of hypercholesterolemia. In a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chiba, Tomohiro, Sakurada, Tsuyoshi, Watanabe, Rie, Yamaguchi, Kohji, Kimura, Yasuhisa, Kioka, Noriyuki, Kawagishi, Hirokazu, Matsuo, Michinori, Ueda, Kazumitsu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281142/
https://ncbi.nlm.nih.gov/pubmed/25551765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116162
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