ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding

ATP-binding cassette protein A1 (ABCA1) plays a major role in cholesterol homeostasis and high-density lipoprotein (HDL) metabolism. Although it is predicted that apolipoprotein A-I (apoA-I) directly binds to ABCA1, the physiological importance of this interaction is still controversial and the conf...

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Detalhes bibliográficos
Main Authors: Nagao, Kohjiro, Takahashi, Kei, Azuma, Yuya, Takada, Mie, Kimura, Yasuhisa, Matsuo, Michinori, Kioka, Noriyuki, Ueda, Kazumitsu
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243469/
https://ncbi.nlm.nih.gov/pubmed/22028339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M019976
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