Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation

The quality and quantity of high-density lipoprotein (HDL) in blood plasma are important for preventing coronary artery disease. ATP-binding cassette protein A1 (ABCA1) and apolipoprotein A-I (apoA-I) play essential roles in nascent HDL formation, but controversy persists regarding the mechanism by...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Ishigami, Masato, Ogasawara, Fumihiko, Nagao, Kohjiro, Hashimoto, Hidehiko, Kimura, Yasuhisa, Kioka, Noriyuki, Ueda, Kazumitsu
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5906560/
https://ncbi.nlm.nih.gov/pubmed/29670126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24428-6
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