ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner

ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile. Because SM depletion increases cellular PC content and stimulates PC and cholesterol efflux by ABCA1, a key transporter involved in generation of HDL, we predicted that SM d...

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Vydáno v:J Lipid Res
Hlavní autoři: Zhao, Yu, Ishigami, Masato, Nagao, Kohjiro, Hanada, Kentaro, Kono, Nozomu, Arai, Hiroyuki, Matsuo, Michinori, Kioka, Noriyuki, Ueda, Kazumitsu
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2015
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340311/
https://ncbi.nlm.nih.gov/pubmed/25601960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M056622
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