ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner

ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile. Because SM depletion increases cellular PC content and stimulates PC and cholesterol efflux by ABCA1, a key transporter involved in generation of HDL, we predicted that SM d...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Zhao, Yu, Ishigami, Masato, Nagao, Kohjiro, Hanada, Kentaro, Kono, Nozomu, Arai, Hiroyuki, Matsuo, Michinori, Kioka, Noriyuki, Ueda, Kazumitsu
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340311/
https://ncbi.nlm.nih.gov/pubmed/25601960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M056622
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