ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner

ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile. Because SM depletion increases cellular PC content and stimulates PC and cholesterol efflux by ABCA1, a key transporter involved in generation of HDL, we predicted that SM d...

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Dettagli Bibliografici
Pubblicato in:J Lipid Res
Autori principali: Zhao, Yu, Ishigami, Masato, Nagao, Kohjiro, Hanada, Kentaro, Kono, Nozomu, Arai, Hiroyuki, Matsuo, Michinori, Kioka, Noriyuki, Ueda, Kazumitsu
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340311/
https://ncbi.nlm.nih.gov/pubmed/25601960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M056622
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