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Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol
MDR1 (multidrug resistance 1)/P-glycoprotein is an ATP-driven transporter which excretes a wide variety of structurally unrelated hydrophobic compounds from cells. It is suggested that drugs bind to MDR1 directly from the lipid bilayer and that cholesterol in the bilayer also interacts with MDR1. Ho...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Portland Press Ltd.
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1820799/ https://ncbi.nlm.nih.gov/pubmed/17029589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060632 |
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