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In vivo FRET analyses reveal a role of ATP hydrolysis–associated conformational changes in human P-glycoprotein
P-glycoprotein (P-gp; also known as MDR1 or ABCB1) is an ATP-driven multidrug transporter that extrudes various hydrophobic toxic compounds to the extracellular space. P-gp consists of two transmembrane domains (TMDs) that form the substrate translocation pathway and two nucleotide-binding domains (...
Zapisane w:
| Wydane w: | J Biol Chem |
|---|---|
| Główni autorzy: | , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Biochemistry and Molecular Biology
2020
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7152753/ https://ncbi.nlm.nih.gov/pubmed/32111736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012042 |
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