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The crystal structure of the CmABCB1 G132V mutant, which favors the outward‐facing state, reveals the mechanism of the pivotal joint between TM1 and TM3
CmABCB1 is a homologue of human P‐glycoprotein, which extrudes various substrates by iterative cycles of conformational changes between the inward‐ and outward‐facing states. Comparison of the inward‐ and outward‐facing structures of CmABCB1 suggested that pivotal joints in the transmembrane domain...
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| Publicado no: | Protein Sci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Inc.
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8040855/ https://ncbi.nlm.nih.gov/pubmed/33683740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.4058 |
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