Cardiac-Specific Knockout of Lmod2 Results in a Severe Reduction in Myofilament Force Production and Rapid Cardiac Failure

Leiomodin-2 (Lmod2) is a striated muscle-specific actin binding protein that is implicated in assembly of thin filaments. The necessity of Lmod2 in the adult mouse and role it plays in the mechanics of contraction are unknown. To answer these questions, we generated cardiac-specific conditional Lmod...

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Bibliographic Details
Published in:J Mol Cell Cardiol
Main Authors: Pappas, Christopher T., Farman, Gerrie P., Mayfield, Rachel M., Konhilas, John P., Gregorio, Carol C.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6324932/
https://ncbi.nlm.nih.gov/pubmed/30102883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2018.08.009
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